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Simulation of hypoxia PET-tracer uptake in tumours: Dependence of clinical uptake-values on transport parameters and arterial input function
Institution:1. German Cancer Research Center (DKFZ), Department of Medical Physics in Radiation Oncology, Heidelberg, Germany;2. Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany;3. Heidelberg University, Faculty of Physics and Astronomy, Heidelberg, Germany;4. Pontificia Universidad Católica de Chile, Institute of Physics, Santiago, Chile;5. Universidad de Chile, Center for Mathematical Modeling, Santiago, Chile;6. University of Groningen, Johann Bernoulli Institute, Groningen, The Netherlands;7. Instituto de Investigación Sanitaria de Santiago (IDIS), Group of Medical Physics and Biomathematics, Santiago de Compostela, Spain;1. Department of Oncotherapy, University of Szeged, Szeged, Korányi fasor 12, Zip Code: 6720, Hungary;2. General Electric Healthcare Company, Budapest, Bence u. 3, Zip Code: 1131, Hungary;1. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran;2. Research Center for Molecular and Cellular Imaging (RCMCI), Tehran University of Medical Sciences, Tehran, Iran;3. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. PET/CT and Cyclotron Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Department of Biomedical Engineering, Washington University in St. Louis, USA;6. Mallinckrodt Institute of Radiology, Washington University in St. Louis, USA;7. Departments of Radiology and Physics, University of British Columbia, Vancouver, Canada;8. Department of Integrative Oncology, BC Cancer Research Center, Vancouver, Canada;1. Department of Clinical and Experimental Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, Italy;2. Health Physics Unit, AOU Careggi, 50134 Florence, Italy;3. Medical Physics Unit, AOU Careggi, 50134 Florence, Italy;4. Radiotherapy Unit, AOU Careggi, 50134 Florence, Italy;5. Neurosurgery Unit, AOU Careggi, 50134 Florence, Italy;1. Department of Radiation Oncology, Dong Nai General Hospital, Bien Hoa, Viet Nam;2. Chi Anh Medical Technology Co., Ltd., Ho Chi Minh, Viet Nam;3. Faculty of Physics & Engineering Physics, University of Science, Ho Chi Minh, Viet Nam;4. PTW-Asia Pacific Ltd, Hong Kong;1. Medical Physics Laboratory, AHEPA University Hospital, Aristotle University of Thessaloniki, 541 24, Greece;2. 2nd Nuclear Medicine Laboratory, AHEPA University Hospital, Aristotle University of Thessaloniki, 541 24, Greece
Abstract:
Keywords:Hypoxia tracer uptake  Positron-emission-tomography (PET)  Radiotherapy  Computer simulation
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