Primary gastric T cell lymphoma mimicking marginal zone B cell lymphoma of mucosa-associated lymphoid tissue |
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| Authors: | Danniele Holanda Merry Y. Zhao Aaron P. Rapoport Michael Garofalo Qing Chen X. Frank Zhao |
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| Affiliation: | 1Department of Pathology, School of Medicine, University of Maryland, Baltimore, 22 South Greene Street, Room NBW78, Baltimore, MD 21201 USA ;2Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD 21201 USA ;3Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, Baltimore, MD 21201 USA |
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| Abstract: | Primary gastric T cell lymphoma is rare and mostly of large cell type. In this paper, we present a case of gastric T cell lymphoma morphologically similar to the gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT). Morphologically, the cells are small with abundant clear cytoplasm. Lymphoepithelial lesions are readily identified with diffuse destruction of gastric glands. Immunohistochemically, the neoplastic cells are CD3+/CD4+/CD8−/Granzyme B−. Molecular studies revealed monoclonal T cell receptor γ gene rearrangement. Clinically, the patient responded initially to four cycles of R-CHOP, but then progressed. Because peripheral T cell lymphoma is usually associated with a poor prognosis, whereas marginal zone B cell lymphoma is an indolent lymphoproliferative disorder, this morphologic mimicry should be recognized and completely investigated when atypical small lymphoid infiltrates with lymphoepithelial lesions are encountered in the stomach. |
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| Keywords: | Primary gastric T cell lymphoma MALT H. pylori HTLV-1 |
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