Effect of Immune Priming on Borna Disease |
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Authors: | Ann J Lewis J Lindsay Whitton Carolyn G Hatalski Herbert Weissenbck and W Ian Lipkin |
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Institution: | Ann J. Lewis, J. Lindsay Whitton, Carolyn G. Hatalski, Herbert Weissenböck, and W. Ian Lipkin |
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Abstract: | Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity. |
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