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Characterization of the seminal plasma proteome in men with prostatitis by mass spectrometry
Authors:Daniel Kagedan  Irene Lecker  Ihor Batruch  Christopher Smith  Ilia Kaploun  Kirk Lo  Ethan Grober  " target="_blank">Eleftherios P Diamandis
Institution:(1) Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada;(2) Division of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Canada;(3) Department of Pathology and Laboratory Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada;(4) Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada;(5) Institute of Medical Sciences, University of Toronto, Toronto, Canada
Abstract:

Background  

Prostatitis is an inflammation of the prostate gland which affects approximately 10% of men. Despite its frequency, diagnosing prostatitis and monitoring patient response to treatment remains frustrating. As the prostate contributes a substantial percentage of proteins to seminal plasma, we hypothesized that a protein biomarker of prostatitis might be found by comparing the seminal plasma proteome of patients with and without prostatitis.
Keywords:prostatitis  seminal plasma  inflammation  biomarkers  mass spectrometry
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