The Good,the Bad,and the Ugly: in search of gold standards for assessing functional genetic screen quality |
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| Authors: | Bastiaan Evers Rene Bernards Roderick L Beijersbergen |
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| Institution: | Division of Molecular Carcinogenesis and Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, , Amsterdam, The Netherlands |
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| Abstract: | Variable screen quality, off‐target effects, and unclear false discovery rates often hamper large‐scale functional genomic screens in mammalian cells. Hart et al (2014) introduce gold standard reference sets of essential and non‐essential genes, aiming at standardizing the analysis of genome‐wide screens. This work provides a framework to compare both the quality and analysis methods of functional genetic screens. |
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