Prion permissive pathways: extracellular matrix genes control susceptibility to prion infection |
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Authors: | Thibaut Imberdis David A Harris |
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Affiliation: | Department of Biochemistry, Boston University School of Medicine, , Boston, MA, USA |
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Abstract: | There are wide variations in the susceptibility of humans, animals, and cultured cell lines to infection by prions. In this issue of The EMBO Journal, Marbiah et al ( 2014 ) identified a gene regulatory network that regulates the susceptibility of cultured cells to prion infection. Surprisingly, a number of these genes impact the structure of the extracellular matrix. These results have important implications for understanding mechanisms of prion infection and also suggest new therapeutic targets. |
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