NAD+ controls neural stem cell fate in the aging brain |
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| Authors: | Christopher Wiley Judith Campisi |
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| Institution: | 1. Buck Institute for Research on Aging, , Novato, CA, USA;2. Lawrence Berkeley National Laboratory, , Berkeley, CA, USA |
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| Abstract: | Loss of the coenzyme NAD+, which is required for many energy‐dependent cellular processes, has emerged as a potentially unifying mechanism for age‐related conditions. A study in this issue of The EMBO Journal identifies a novel link between depletion of NAD+ and age‐associated loss of proliferating adult neural stem/progenitor cells in the murine brain (Stein & Imai, 2014 ). These data have important implications for how brain function might decline with age. |
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