Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis (Leguminosae) |
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| Authors: | Silva Geraldo Humberto Teles Helder Lopes Zanardi Lisinéia Maria Marx Young Maria Claudia Eberlin Marcos Nogueira Hadad Renato Pfenning Ludwig H Costa-Neto Claudio Miguel Castro-Gamboa Ian da Silva Bolzani Vanderlan Araújo Angela Regina |
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| Affiliation: | NuBBE-Núcleo de Bioensaio, Biossíntese e Ecofisiologia de Produtos Naturais, Instituto de Química, Universidade Estadual Paulista, CP 355, CEP 14801-970, Araraquara, SP, Brazil. |
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| Abstract: | Five cadinane sesquiterpenes derivatives were isolated by bioassay-guided fractionation from Phomopis cassiae, an endophytic fungus isolated from Cassia spectabilis. The structures of the two diastereoisomeric 3,9,12-trihydroxycalamenenes (1, 2); 3,12-dihydroxycalamenene (3); 3,12-dihydroxycadalene (4) and 3,11,12-trihydroxycadalene (5) were established on the basis of analyses of 1D and 2D NMR and HRTOFMS experiments. Antifungal activity of the isolates was evaluated against Cladosporium sphaerospermum and Cladosporium cladosporioides, revealing 5 as the most active compound. |
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| Keywords: | Phomopsis Endophytic fungi Cadinane Sesquiterpenes Antifungal |
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