Regional differences in dosage compensation on the chicken Z chromosome |
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| Authors: | Esther Melamed Arthur P Arnold |
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| Affiliation: | (1) Department of Physiological Science, and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA 90095-1606, USA |
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| Abstract: | Background Most Z chromosome genes in birds are expressed at a higher level in ZZ males than in ZW females, and thus are relatively ineffectively dosage compensated. Some Z genes are compensated, however, by an unknown mechanism. Previous studies identified a non-coding RNA in the male hypermethylated (MHM) region, associated with sex-specific histone acetylation, which has been proposed to be involved in dosage compensation. |
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