| PIP2信号与PIP2的再合成 |
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| 引用本文： | 徐佳曦,;阎向东,;司曼,;丁杰,;杜雨薇,;张海林.PIP2信号与PIP2的再合成[J].细胞生物学杂志,2014(11):1543-1550. |
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| 作者姓名： | 徐佳曦 ;阎向东 ;司曼 ;丁杰 ;杜雨薇 ;张海林 |
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| 作者单位： | [1]河北医科大学药理教研室,石家庄050017; [2]河北省中医药科学院,石家庄050031 |
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| 基金项目： | 国家自然科学基金（批准号：31270882）;国家重点基础研究发展计划（973计划）（批准号：2013CB531302）资助的课题 |
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| 摘 要： | 磷脂酰肌醇-4,5-二磷酸（phosphatidylinositol-4,5-bisphosphate,PIP2）是一种分布在细胞膜内侧面的微量磷脂。虽然含量很低,但PIP2在细胞信号转导以及膜蛋白功能调节等方面却起着十分重要的作用。细胞膜中PIP2的含量水平呈动态平衡,在其代谢调节改变时,PIP2局部浓度的变化可影响特定蛋白的功能。该文就近二十年来针对PIP2信号和PIP2代谢调节相关的研究作一综述。
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| 关 键 词： | PIP2 PIP2信号特异性 PIP2代谢循环 |
The Specificity and Turnover of PIP2 Signal |
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| Institution: | Xu Jiaxi, Yan Xiangdong, Si Man, Ding Jie, Du Yuwei, Zhang Hailin (1Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China; 2Hebei Traditional Chinese Medicine Research Institution, Shijiazhuang 050031, China) |
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| Abstract: | Phosphatidylinositol-4,5-bisphosphate（PIP2） is a type of phosphoinositide enriched in the inner leaflet of the plasma membrane.Though PIP2 only comprises about 1% of plasma membrane phospholipids,it serves as a precursor of the second messengers,and stabilizes or activates many important membrane proteins.Cellular PIP2 levels are dynamically regulated.When the metabolic regulation of PIP2 is changed,the resulted changes in the local concentration of PIP2 will alter the function of a specific protein.This paper reviewed the researches on some aspects of PIP2 signal and its metabolic characteristics in the last two decades. |
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| Keywords: | PIP2 specificity of PIP2 signal PIP2 turnover |
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