Inhibitory effect of a peptide leukotriene antagonist ONO-1078 on LTD4- and antigen-induced thromboxane B2 production in guinea pig lungs |
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Institution: | 1. College of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao 266590, China;2. Department of Computer Science, Brunel University London, Uxbridge, Middlesex UB8 3PH, United Kingdom;3. School of Mathematics and Physics, Anhui Polytechnic University, Wuhu 241000, China |
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Abstract: | The effect of a peptide leukotriene receptor antagonist ONO-1078 on the production of thromboxane (Tx) B2 induced by leukotriene (LT) D4 and antigen challenge was examined in guinea pig lungs. LTD4 (1–1,000 nM) induced a concentration-dependent production of TxB2 in nonsensitized guinea pig lungs and ovalbumin challenge (0.01–100 μg/ml) produced TxB2 and peptide leukotrienes in a concentration-dependent manner in ovalbumin-sensitized guinea pig lungs. ONO-1078 inhibited LTD4 (100 nM)-induced TxB2 production with the IC50 value of 0.24 μM. Furthermore, ONO-1078 inhibited antigen (10 μg/ml)-induced TxB2 production with the IC50 value of 0.14 μM without effect on the production of peptide leukotrienes. These results suggest that ONO-1078 may prevent the antigen-induced production of TxB2 through the blockade of the activation of receptors by endogenously generated peptide leukotrienes. |
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