Endocytosis and Presentation of Liposome-Associated Antigens by B Cells |
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Institution: | 1. Charité University Medicine Berlin, Institute of Transfusion Medicine, Robert-Koch Platz 3, 10115 Berlin, Germany;2. Clinical Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt;1. University of Alberta, Edmonton, AB, Canada;2. Alberta Diabetes Institute, Edmonton, AB, Canada |
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Abstract: | B cells have limited endocytic capacity and are reported to endocytose and present liposome-encapsulated antigens poorly. B cells also endocytose soluble antigens poorly, except those for which their surface immunoglobulin is specific, which are taken up and presented efficiently. We present results indicating that, in vitro, B cells endocytose small liposomes bearing antigen with affinity for their surface immunoglobulin. Antigen encapsulated in liposomes targeted by antibody specific for surface immunoglobulin is presented to T cells as efficiently as specific antigen in soluble form. These studies provide a rational basis for the design of liposomes optimized to stimulate T-dependent B-cell responses. |
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