Effects of in vivo morphine treatment on antibody responses in C57BL/6 bgJ/bgJ (beige) mice |
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| Institution: | 1. Department of Biochemistry, ICMR-National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, Uttar Pradesh, India;2. Department of Community Medicine, Gouri Devi Institute of Medical Sciences & Hospital, Durgapur, West Bengal, India;3. ICMR-National Institute of Occupational Health, Ahmedabad, Gujarat, India;1. Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA;2. Wadsworth Center, New York State Department of Health, Albany, New York, USA;3. Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA;4. Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA;1. Key Laboratory of Chemical Engineering Process and Technology for High-efficiency Conversion, College of Chemistry and Material Sciences, Heilongjiang University, Harbin 150080, China;2. Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150080, China;3. Key Laboratory of Microbiology, College of Heilongjiang Province, School of Life Science, Heilongjiang University, Harbin 150080, China;4. Bluesky Biotech (Harbin) Co., Ltd., Harbin 150028, China;1. Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, PR China;2. Department of Urology, Guangzhou Women and Children''s Medical Center, Guangzhou Medical University, Guangzhou 510623, PR China;3. Department of Urology, The First Affiliated Hospital, Southwest Medical University, Luzhou 646000, PR China;4. Department of Urology, Peking University Shenzhen Hospital, Shenzhen 518036, PR China;5. Department of Pathogen Biology and Experimental Teaching Center of Preventive Medicine, Guangdong Provincial Key Laboratory of Tropical Disease, School of Public Health, Southern Medical University, Guangzhou 510515, PR China;1. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China;2. College of Animal Science, Zhejiang University, Hangzhou, China |
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| Abstract: | C57BL/6J bgJ/bgJ (beige) mice are less sensitive than other strains to the analgesic effects of morphine, although they have normal numbers of μ receptors. In the present study, beige mice and their normal littermates (beige+) were treated in vivo with morphine or the opioid antagonist, naltrexone and their primary in vitro antibody responses were assessed. Morphine treatment caused splenic atrophy and suppressed the primary in vitro antibody response in beige and beige+ mice. However, these effects were not blocked by naltrexone co-treatment. In these mouse strains, naltrexone decreased spleen size and antibody responses by itself, which may mask its ability to antagonize morphine. In beige mice, placebo pellet implantation suppressed the primary in vitro antibody response. Morphine did not cause a further suppression of the antibody response in beige mice compared to placebo. Because of this anomalous response to placebo treatment, the immunosuppressive effects of morphine on the antibody response/107 cells can not be attributed to a specific drug effect in this strain. However, when antibody responses were expressed on a per spleen basis, the overall capacity to respond to antigenic challenge was suppressed by morphine treatment. |
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