Phosphoramidon potentiates the bronchoconstriction induced by inhaled bombesin in guinea pigs |
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| Institution: | 2. Institut Henri Beaufour, 1 avenue des Tropiques, 91952 Les Ulis, France;1. Bio-Inova Res. Lab., 48-52 rue de la Gare, 78370 Plaisir, France;1. Department of Organic Chemistry, V.N. Karazin Kharkiv National University, Svobody sq., 4, 61022 Kharkiv, Ukraine;2. SSI “Institut for Single Crystals” NAS of Ukraine, Nauki ave, 60, 61001 Kharkiv, Ukraine;1. ols-Med General Practice, Bartoszyce, Poland;2. Department of Nephrology, Hypertension and Internal Medicine, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Poland;3. Department of Cardiology and Cardiac Surgery, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Poland |
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| Abstract: | The effect of the neutral endopeptidase inhibitor, phosphoramidon, on the bronchoconstriction induced by aerosolized bombesin in the guinea pig was investigated. Administered by aerosol for 1 min, bombesin (0.01 or 0.1 mg/ml) induced a dose-dependent increase in pulmonary inflation pressure. Pretreatment of the guinea-pigs with phosphoramidon (0.1 mM), administered by aerosol for 15 min, 15 min prior to challenge, markedly potentiated the increase in pulmonary inflation pressure induced by bombesin (0.01 mg/ml) and substance P (0.1 mg/ml). This result suggests a local hydrolysis of bombesin by airway neutral endopeptidase reducing the activity of this peptide on smooth muscle. |
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