Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome |
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Affiliation: | 1. DECHEMA-Forschungsinstitut, Theodor-Heuss-Allee 25, 60486 Frankfurt am Main, Germany;2. Fraunhofer Institute for Ceramic Technologies and Systems, Winterbergstrasse 28, 01277 Dresden, Germany |
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Abstract: | Neuropeptide FF (NPFF) has been shown to exert various antiopiate actions, including precipitation of opiate abstinence syndrome by third ventricle injection in morphine dependent rats. In the present study, dansyl-Pro-Gln-Arg-Phe-amide, a lipophilic analog of NPFF, was injected into morphine dependent rats and appropriate sham controls at a dose of 9 mg/kg s.c. Comparison groups were injected with ethanol/water vehicle alone. The NPFF analog precipitated a vigorous opiate abstinence syndrome in morphine dependent rats, but not in sham controls. |
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