Comparative structural analysis of human and rat 65 kDa tumor-associated phosphoproteins |
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| Affiliation: | 1. Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000, Zagreb, Croatia;2. University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Studentski trg 12-16, 11000, Beograd, Serbia;3. Centre of Excellence in Environmental Chemistry and Engineering, ICTM, 11000, Belgrade, Serbia;4. University of Belgrade, Faculty of Chemistry, Studentski trg 12-16, 11158, Belgrade, Serbia;1. Institute for Geography and Geoecology, KIT Karlsruhe, Kaiserstr. 12, 76131 Karlsruhe, Germany;2. Institute of Geography, FAU Erlangen-Nuernberg, Wetterkreuz 15, 91058 Erlangen, Germany;3. Institute for Geoinformatics and Remote Sensing, University of Osnabrueck, Barbarastraße 22b, 49076 Osnabrueck, Germany;1. Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC;2. Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC;3. Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan, Taiwan, ROC;4. Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC;5. Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan, ROC;6. Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, NY, USA |
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| Abstract: | - 1.1. A 65 kDa-tumor-associated protein (p65) was isolated from human and rat carcinoma cell culture media. Antibodies raised to the rat protein recognized an antigenically related protein in human cancer cell line.
- 2.2. Amino acid composition, N-terminal and internal sequence as well as peptide map and western blot analysis of the p65 strongly suggest a high degree of homology between the human and rat p65 proteins.
- 3.3. Homology searches indicated that p65 was not homologous to previously sequenced proteins, but that it may be related to proteins of the steroid receptor superfamily of genes, especially c-erb A gene.
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