Effect of lindane on phosphatidylinositol synthesis by cerebral cortex after acute and subchronic treatment |
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Institution: | 1. Departement of Biochemistry, Cell and Molecular Biology & Center for Research on Nutrition, Metabolism, and Diabetes, Third Faculty of Medicine, Charles University, Prague, Czech Republic;2. Department of Hygiene, Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Prague 10, Czech Republic |
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Abstract: | - 1.1. The incorporation of myo-2-3H]inositol into phosphatidylinositols was unmodified in brain cortex miniprisms from convulsant rats.
- 2.2. However, the incorporation had increased by 300–400% in non convulsant rats which had received the same amount of lindane at a lower concentration.
- 3.3. This result suggests that phosphatidylinositols are implicated in the convulsion syndrome.
- 4.4. Experiments with lindane added in vitro were performed with both subchronically lindane intoxicated and untreated rats.
- 5.5. The results show an interesting lack of parallelism.
- 6.6. This might indicate the development of some resistance to the effects of lindane, possibly as the result of complex compensatory changes in inositol lipid biosynthesis.
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