Energy metabolism of human erythrocytes in psoriasis |
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Affiliation: | 1. Department of Public Health of Ukraine, Research Institute of Dermatology and Venerology, Khar''kov 310057, Ukraine;2. Institute of Theoretical and Experimental Biophysics, The Russian Academy of Sciences, Pushchino 142292, Russia |
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Abstract: | - 1.1. Adenine nucleotide concentrations and metabolism in red blood cells (RBC)2 and RBC ghosts from psoriatic patients and healthy subjects were compared.
- 2.2. The ATP and total adenine nucleotide levels and the adenylate energy charge (EC) were elevated in the blood from psoriatic patients.
- 3.3. The rate of glycolytic production of ATP by intact RBC was unchanged, but the Na+, K+-ATPase activity of RBC ghosts was decreased significantly in psoriasis.
- 4.4. Results suggest that the defect in adenine nucleotide metabolism is a systemic manifestation of psoriasis, and that the quantification of adenine nucleotides in RBC and in whole blood samples may be of pathophysiological value in psoriatic lesion.
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