Regulation of spermidine transport in l1210 cells |
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Affiliation: | Sezione di Biochimica del Dipartimento di Medicina e Oncologia Sperimentale, Universita'' di Torino, 10126 Turin, Italy [Fax 011-670-7770] |
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Abstract: | - 1.1. 1 mM 2-amino isobutyric add (AIB), glutamine or asparagine when preincubated for 3 hr with L1210 cells promoted a marked increase in the rate of spermidine uptake.
- 2.2. Cycloheximide also increased the transport rate and completely prevented the increase due to AIB.
- 3.3. Trifluoperazine and iso-H7 inhibited the uptake of spermidine, much less the uptake of AIB.
- 4.4. Adenosine promoted an increase in the uptake of AIB, a decrease in that of spermidine.
- 5.5. Hypotonic stress also increased the rate of spermidine transport. This modification was only partially prevented by cycloheximide.
- 6.6. Okadaic arid had no effect on this increase, whereas it prevented the increase of ODC activity.
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