Inhibitory action of azelastine on cytokine production from human peripheral blood leukocytes in vitro |
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| Affiliation: | 1. First Department of Internal Medicine, Showa University, Hatanodai, Shinagawa-ku, Tokyo 142, Japan;2. Department of Medical Biology, School of Medicine, Showa University, Hatanodai, Shinagawa-ku, Tokyo 142, Japan;1. Department of Dermatology and Venerology, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing, 100034, China;2. Cancer Research Center, Beijing Chest Hospital, Capital Medical University & Beijing Tuberculosis and Thoracic Tumor Research Institute, No.9 Beiguan Street, Tongzhou District, Beijing, 101149, China;3. Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, 37 Xueyuan Road, Haidian District, Beijing, 100083, China;4. Department of Dermatology and Venerology, Civil Aviation General Hospital, 1 Gaojing A, Chaoyang District, Beijing, 100123, China;5. Department of Gastroenterology, Civil Aviation General Hospital, 1 Gaojing A, Chaoyang District, Beijing, 100123, China;1. Instituto de Ecología, A. C., Apartado Postal 63, CP 91000, Xalapa, Veracruz, Mexico;2. Inbioteca, Universidad Veracruzana, Av. Culturas Veracruzanas No.101, Col. E. Zapata, CP 91090, Xalapa, Veracruz, Mexico;3. School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand |
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| Abstract: | Effects of azelastine (AZ) on human peripheral blood leukocytes (PBL) in culture were examined. Addition of 10.0 μg/ml of AZ resulted in a marked inhibition of PBL blastic activity, but lower concentrations (1.0 and 0.5 μg/ml) had no demonstrable suppressive effects on the activation. Interleukin (IL)-2, IL-3 and IL-4 production from PBL in response to Concanavalin A stimulation was also strongly suppressed when the cells were cultured in the presence of AZ. This suppression was observed even when lower concentrations (1.0 and 0.5 μg/ml) of AZ were added to cell cultures |
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