Chromosomal aberrations induced in vitro by 3,7- and 3,9-dinitrofluoranthene |
| |
| Institution: | 1. Department of Marketing, Copenhagen Business School, Solbjerg Plads 3, DK-2000 Frederiksberg, Denmark;2. Department of Business IT, IT University of Copenhagen, Rued Langgaards Vej 7, DK-2300 Copenhagen S, Denmark;3. Department of Strategy and Innovation, Copenhagen Business School, Kilevej 14A, DK-2000 Frederiksberg, Denmark;1. Izmir Institute of Technology, Department of Molecular Biology and Genetics, 35430 Urla, Izmir, Turkey;2. Inonu University, Medical School, Department of Medical Biology and Genetics, Battalgazi, Malatya, Turkey |
| |
| Abstract: | The chromosomal aberration test using a Chinese hamster cell line (CHL) was carried out with 3,7- and 3,9-dinitrofluoranthene (DNF) with and without exogenous metabolic activation (rat liver S9 mix). The highest dose tested was limited to 20 μg/ml because of the compounds' insolubility in dimethyl sulfoxide. Both DNFs induced chromosomal aberrations in the absence of S9 mix; the frequency was not very high. Results were reproducible, but without clear dose-response relationships. Neither DNF induced chromosomal aberrations in the presence of S9 mix. Both DNFs did not induce polyploid cells under any conditions. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
