Decreased sensitivity of aorta from hypertensive rats to vasorelaxation by tyrphostin |
| |
| Institution: | 1. Department of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran;2. Independent Researcher in Mechanical Engineering;3. School of Engineering and Information Technology, University of New South Wales Canberra, Canberra, ACT 2610, Australia;4. Faculty of Engineering, Kuwait College of Science and Technology, Doha District, Kuwait;5. Center of Excellence in Desalination Technology, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia;6. Depatment of Chemical and Materials Engineering, Faculty of Engineering, King Abdulaziz University, Jeddah 21589, Saudi Arabia;7. Center of Research Excellence in Renewable Energy and Power System, King Abdulaziz University, Jeddah 21589, Saudi Arabia;8. School of Engineering and Materials Science, Queen Mary University of London, London E14NS, United Kingdom |
| |
| Abstract: | The role of protein tyrosine kinases (PTKs) in vascular smooth muscle (VSM) contraction was examined in spontaneously hypertensive rats (SHRs). Aorta from SHRs was hyperresponsive to PTK-mediated contraction relative to normotensive Wistar-Kyoto rats (WKYs). Aorta from SHR was also hyporesponsive to vasorelaxation by tyrphostin, a selective inhibitor of PTKs. Further, we found alterations in PTK activity in aorta from SHRs. PDGF stimulated PTK activity to a greater extent in the SHR. Tyrphostin inhibited PDGF-induced PTK stimulation in both strains, however, activity returned to basal levels in the WKY only. The results suggest that PTKs may be involved in VSM contraction and in the development of hypertension. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
