D-d-lactoylglutathione accumulation in activated human platelets |
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| Affiliation: | 1. School of Industrial Technology, University Sains Malaysia, George Town 11800, Penang, Malaysia;2. School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;1. Department of Nephrology and Hypertension, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain;2. RICORS2040 (Redes de Investigación Cooperativa Orientadas a Resultados en Salud), Madrid, Spain;3. Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain;4. Departamento de Medicina, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain;5. Departamento de Farmacología, Universidad Autonoma de Madrid (UAM), Madrid, Spain;6. Translational Immunology, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain;7. Department of Pathology, IIS–Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain;1. Department of Mathematics, University of North Carolina, Chapel Hill, NC 27599, USA;2. School of Mathematics and Statistics F07, University of Sydney, Sydney, NSW 2006, Australia;3. Department of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA;4. Departamento de Matemáticas y Mecánica, Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, Universidad Nacional Autónoma de México, Apdo. Postal 20-126, C.P. 01000, México, D.F., Mexico;1. Dept. of Natural Sciences and Mathematics, West Liberty University, West Liberty, WV 26074, United States;2. Dept. of Graduate Health Sciences, West Liberty University, West Liberty, WV 26074, United States;3. Northeast Ohio Medical University, Rootstown, OH 44272, United States;4. West Virginia University School of Medicine, Morgantown, WV 26506, United States |
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| Abstract: | - 1.1. S-d-Lactoylglutathione accumulates in human platelets activated by agonists. Among the tested inducers thrombin is the most active.
- 2.2. The effect is dose and time-dependent. S-d-Lactoylglutathione, corresponding to depleted pool of reduced glutathione, can also be detected in platelets incubated with exogenous methylglyoxal.
- 3.3. A further significant increase was observed in platelets stimulated with trombin in the presence of methylglyoxal.
- 4.4. No change in glyoxalase activities upon platelet stimulation with thrombin was shown.
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