Etonitazene: An opioid selective for the mu receptor types |
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| Affiliation: | 1. CIToxLAB North America, 445 Armand Frappier, Laval, QC, Canada, H7V 4B3;2. Faculty of Veterinary Medicine, University of Montreal, P.O. Box 5000, St-Hyacinthe, QC, Canada, J2S 7C6;3. SCIREQ Scientific Respiratory Equipment Inc., 6600 St-Urbain, Montreal, QC, Canada, H2S 3G8;4. THORASYS Thoracic Medical Systems Inc., 6600 rue St-Urbain, Montreal, QC, Canada, H2S 3G8 |
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| Abstract: | Specific radioligand binding protocols were utilized to compare the affinity of morphine and the high-potency opioid etonitazene at mu1, mu2, delta, kappa1 and sigma receptors. Both etonitazene and morphine displayed a mu1-selective binding profile; however, etonitazene had a 2500-fold higher affinity at this receptor type. The latter result is consistent with the relative potencies of morphine and etonitazene in various behavioral tests. |
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