Concanavalin a enhances ATP resynthesis via de novo pathway in postischemic rat hearts |
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| Affiliation: | 1. Department of Surgery, Colorado Health Sciences Center, Denver 80262, USA;1. Department of Chemical Engineering, University of Ottawa, Canada K1N 6N5, USA;1. The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong;2. The Xiangtan Central Hospital, Xiangtan, Hunan;3. Guangdong Provincial People’s Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong;4. Dongguan Ninth People''s Hospital, Dongguan, Guangdong;5. The Second People’s Hospital of Zhongshan, Zhongshan, Guangdong;6. Dongguan People''s Hospital, Dongguan, Guangdong, China;1. International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;2. Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;3. Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, China;4. Hangzhou Women’s Hospital, Hangzhou, Zhejiang, China;5. Dalian Maternal and Childcare Health Hospital, Dalian, Liaoning, China;6. Wenzhou People’s Hospital, Wenzhou, Zhejiang, China;7. Jiashan Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China;8. Fuzhou Maternal and Child Health Care Hospital, Fuzhou, Jiangxi, China;9. Songjiang Maternity and Child Health Hospital, Shanghai, China;10. Hunan Maternal and Child Health Care Hospital, Changsha, Hunan, China;11. Affiliated Hospital of Yan’an University, Yan’an, Shaanxi, China;12. Enze Obstetrics and Gynecology Hospital Affiliated to Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, China;13. Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, China;14. Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China;15. Hainan Women and Children’s Medical Center, Haikou, Hainan, China;p. First People’s Hospital of Wuhu City, Wuhu, Anhui, China;q. People’s Hospital of Changshan, Quzhou, Zhejiang, China;r. Shengzhou Maternity and Child Health Hospital, Shengzhou, Zhejiang, China;s. Wenchang Maternity and Child Health Care Hospital, Wenchang, Hainan, China;t. Huzhou Maternity and Child Health Care Hospital, Huzhou, Zhejiang, China;u. Karamay Central Hospital of XinJiang, Xinjiang, China;v. Ningbo Yinzhou People’s Hospital, Ningbo, Zhejiang, China;w. Fuyang Women and Children’s Hospital, Hangzhou, Zhejiang, China;x. Ningbo Women and Children’s Hospital, Ningbo, Zhejiang, China;y. Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Hangzhou, Zhejiang, China;z. Ningbo University Affiliated Hospital of Medical School, Ningbo, Zhejiang, China;11. School of Public Health, Zhejiang University, Hangzhou, Zhejiang, China;22. Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;33. Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Ontario, Canada;44. Chinese Maternal and Child Health Association, Beijing, China;1. Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;2. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;3. Departments of Molecular Genetics and Computer Science, University of Toronto, Toronto, ON M5S 3E1, Canada;4. Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada;5. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada;6. Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA;7. Boston University School of Medicine, Boston, MA 02118, USA;8. Department of Biological Sciences, Wright State University, Dayton, OH 45435, USA;9. Department of Medical Protein Research, VIB, 9000 Ghent, Belgium;10. Cancer Research Center (Centro de Investigación del Cancer), University of Salamanca and Consejo Superior de Investigaciones Científicas, Salamanca 37008, Spain;11. Joint IRB-BSC Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), Barcelona 08028, Spain;12. Center for Complex Network Research (CCNR) and Department of Physics, Northeastern University, Boston, MA 02115, USA;13. Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA;14. Department of Bioengineering, McGill University, Montreal, QC H3A 0C3, Canada;15. Protein Signaling and Interactions Lab, GIGA-R, University of Liege, 4000 Liege, Belgium;16. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;17. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain;18. Canadian Institute for Advanced Research, Toronto M5G 1Z8, Canada;1. Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;2. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;3. Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;4. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;5. Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;6. Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;7. Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;8. Clinical Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;9. Department of Urology, Wuhan First Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;10. Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;11. Department of Urology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;12. Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;13. Department of Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;14. Department of Respirology and Tuberculosis Specialty, Wuhan Pulmonary Hospital, Wuhan, China;15. Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, China;p. Department of Urology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;q. Department of Urology, The Fifth Hospital of Wuhan, Wuhan, China;r. Department of Respiratory Medicine, Wuhan Hankou Hospital, Wuhan, China |
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| Abstract: | Acute post-ischemic cardiac failure was studied in isolated rat hearts. Xylitol, glutamine, aspartic acid and glycine were added during reperfusion resulting in no inotropic effect. Concanavalin A had a moderate inotropic effect. When concanavalin A added with xylitol, glutamine, aspartic acid and glycine, a rapid recovery of myocardial function and high-energy phosphate was achieved. |
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