In vivo effect of Berenil on rat liver polyamine metabolism |
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| Affiliation: | 1. Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany;2. Regensburg Center for Interventional Immunology (RCI), Regensburg, Germany;3. Department of Medical Oncology and Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands;4. Department of Dermatology, University Hospital of Regensburg, Regensburg, Germany;1. Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France;2. University of Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, 75013 Paris, France;3. Virologie et Immunologie Moléculaire, INRA, Domaine de Vilvert, 78352 Jouy-en-Josas, France;4. Macrophages et Développement de l’Immunité, Institut Pasteur, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France;5. CNRS URA2578, 75724 Paris Cedex 15, France;6. Unité de Génétique Fonctionnelle des Maladies Infectieuses, Institut Pasteur, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France;1. School of Biotechnology, University of Jammu, Jammu and Kashmir, 180006, India;2. Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India;1. Department of Biological Sciences, Florida International University, Miami, FL 33199, USA;2. Laboratory of Molecular Cancer Biology, VIB Center for Cancer Biology, Leuven, Belgium;3. Department of Oncology, KULeuven, Leuven, Belgium;4. Laboratory of Translational Cell and Tissue Research, Department of Pathology, KULeuven and UZ Leuven, Leuven, Belgium;5. Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA |
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| Abstract: | - 1.1. Berenil, administered to rats in vivo, promoted a decrease in liver SAMDC activity, but an increase in ODC and SAT activity.
- 2.2. Its effect on ODC was completely prevented by cycloheximide, that on SAT only partially.
- 3.3. Berenil had no effect on ODC activity in adrenalectomized rats. Adrenergic antagonists counteracted the effect of Berenil on ODC activity.
- 4.4. Polyamine content was increased. The maximum modification was observed for putrescine and N1-acetylspermidine.
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