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Lactoferrin binding to human platelets
Institution:1. Department of Bioinformatics, Rajendra Memorial Research Institute of Medical Sciences, Patna 800007, India;2. Department of Biotechnology and Department of Pharmacoinformatics, National Institutes of Pharmaceutical Education and Research, Hajipur 844102, India;3. Institute for Protein Research, Osaka University, Suita 5650871, Japan;4. Division of Immunology, Rajendra Memorial Research Institute of Medical Sciences, Patna 800007, India;5. Dept. of Molecular Parasitology, Rajendra Memorial Research Institute of Medical Sciences, Patna 800007, India
Abstract:
  • 1.1. Platelets bind specifically lactoferrin.
  • 2.2. The lactoferrin binding to the platelets depends on the concentration of labelled lactoferrin, the number of platelets, the time of incubation and pH.
  • 3.3. The binding was characterized by two types of binding site: one with high affinity and low capacity, and another with low affinity and high capacity (respectively kaff 1 = 13.6 × 1091/mol and about 40 binding sites, and Kaff 2 = 1.23 × 1091/mol and about 135 binding sites per platelet).
  • 4.4. Both human transferrin and bovine lactoferrin compete with human lactoferrin for the receptors.
  • 5.5. The presence of lactoferrin receptors on the platelet membrane surface is connected most probably with the effect(s) on the cell function(s) of these cells.
Keywords:
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