The PACAP receptor: generation by alternative splicing of functional diversity among G protein-coupled receptors in nerve cells |
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| Affiliation: | 1. INMED, INSERM U1249, Marseille, France;2. Aix-Marseille University, Provence, France;3. Cannalab, Cannabinoids Neuroscience Research International Associated Laboratory, INSERM-Aix-Marseille University, Provence, France/Indiana University, Bloomington, IN, USA;4. Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, Italy;5. National Institute of Neuroscience, Cagliari, Italy;6. Department of Science, Section of Biomedical Sciences and Technologies, University ‘Roma Tre’, Rome, Italy |
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| Abstract: | Recent molecular characterization of new G protein-coupled receptors (GPCR) draw attention to alternative splicing as a source of structural diversity. After a brief overview of characterized GPCR splice variants, we will describe in more detail the functional properties of the PACAP type I receptor splice variants. Some of these variants are positively coupled to both adenylate cyclase (AC) and phospholipase C (PLC) whereas others do not elicit any stimulation of the PLC or display a qualitatively intermediate phenotype. The PACAP type I receptor is therefore one of the few examples in which alternative splicing is clearly linked to functional diversity. |
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