Naltrindole,an opioid delta receptor antagonist,blocks cocaine-induced facilitation of responding for rewarding brain stimulation |
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| Affiliation: | 1. Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia;2. Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia;1. Denver Health and Hospital Authority, Denver, CO, United States;2. Department of Medicine, University of Colorado School of Medicine, Denver, CO, United States;3. Institute for Health Research, Kaiser Permanente Colorado, Aurora, CO, United States;4. Colorado Permanente Medical Group, Aurora, CO, United States;1. Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States of America;2. Department of Cell Biology, University of North Carolina, NC, United States of America;3. University of Washington School of Medicine, Seattle, WA, United States of America;4. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States of America;5. Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN, United States of America;6. Department of Pharmacology, University of Minnesota, Minneapolis, MN, United States of America;7. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America |
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| Abstract: | Recent experimental results have led to the suggestion that opioid antagonists can modulate the reinforcing properties of cocaine. In this experiment, rats were fixed with chronically indwelling bipolar electrodes for stimulation of the medial forebrain bundle (MFB) as it courses through the hypothalamus. Rats were taught to press a lever for brief trains of electrical stimulation of the MFB. Subsequently, they were allowed to press for varying intensities of stimulation daily until their response rates were stable. Cocaine (5 mg/kg, s.c.) enhanced the rate of pressing for lower intensities of brain stimulation. Naltrindole (3 mg/kg, i.p.) had no effect on response rate alone but blocked the cocaine-induced facilitation of pressing for rewarding brain stimulation. An implication that can be drawn from these data is that naltrindole, or other delta-selective opioid antagonists, might be effective as medicines for use in treating cocaine abuse. |
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