Effects of short chain fatty acid,sodium butyrate,on osteoblastic cells and osteoclastic cells |
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| Affiliation: | 1. Department of Operational Research, National Institute for Research in Reproductive Health (ICMR), Mumbai, India;2. Department of Obstetrics and Gynecology, Grant Government Medical College and Sir J.J. Group of Hospitals, Mumbai, India;3. Department of Obstetrics and Gynecology, Lokmanya Tilak Municipal General Hospital and Medical College Sion, Mumbai, India;4. Department of Infertility and Endocrinology, National Institute for Research in Reproductive Health (ICMR), Mumbai, India |
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| Abstract: | - 1.1. Sodium butyrate increased alkaline phosphatase (ALP) activity of cloned osteoblastic cell line MC3T3-El by the stimulation of de novo enzyme synthesis.
- 2.2. Sodium butyrate did not affect mature osteoblastic cells but affected preosteoblastic cells.
- 3.3. Sodium butyrate decreased tartrate resistant acid phosphatase (TRACP)-positive multinucleated cells (MNC) formation from bone marrow cells. This related to the cytotoxicity of sodium butyrate on bone marrow cells.
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