Mutagenic activity of some platinum and palladium complexes |
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| Affiliation: | 1. Medical Master Student, Faculty of Medicine & Health Sciences, University of Antwerp, Campus Drie Eiken, Antwerp, Belgium;2. Medical Master Student, Faculty of Medicine & Health Sciences, University of Antwerp, Campus Drie Eiken, Antwerp, Belgium;3. Postdoctoral Researcher, Faculty of Medicine & Health Sciences, University of Antwerp, Campus Drie Eiken, Antwerp, Belgium;1. All for Research vzw, Antwerp, Belgium;2. Department of Cranio-Maxillofacial Surgery, Antwerp University Hospital, Edegem, Belgium;4. Professor, Faculty of Medicine & Health Sciences, University of Antwerp, Campus Drie Eiken, Antwerp, Belgium;3. Department of Maxillofacial Surgery, ZMACK, AZ MONICA Antwerp, Antwerp, Belgium;4. Department of Cranio-Maxillofacial Surgery, Antwerp University Hospital, Edegem, Belgium;1. Exponent, Inc., Health Sciences Center, 1800 Diagonal Road, Alexandria, VA, 22314, USA;2. Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Ontario, K1A 0K9, Canada;3. Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan;1. INRA, Nutrition and Integrative Neurobiology, UMR 1286, 33076 Bordeaux, France;2. CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR 5287, 33076 Bordeaux, France;3. Université de Bordeaux, 33076 Bordeaux, France;4. Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México DF, Mexico;1. Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA;2. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA;3. Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA |
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| Abstract: | The mutagenic properties of 16 platinum compounds were studied using Salmonella typhimurium TA98 and TA100. Eight of the compounds were considered direct mutagens, as their mutagenicity was not dependent on metabolic activation by liver extracts. Potent mutagenicity and high toxicity were exhibited by cis-Pt(NH3)2Br2, cis-Pt(NH3)2Cl2, Pt(C5H12N2)Cl2 and Pt(en)Cl2 for both bacterial strains. When distilled water was used as the carrier solvent, these compounds were strongly mutagenic and toxic, but much less so when dimethyl sulfoxide was the solvent. |
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