Cytogenetic effect of malathion in in vitro culture of human peripheral blood |
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| Affiliation: | 1. Dezful University of Medical Sciences, Dezful, Iran;2. Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran;3. Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran;4. Department of Mathematics, Statistic, and Computer Science, University of Illinois at Chicago, USA;5. Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran;1. Pesticide Science Laboratory, Agricultural University of Athens, 75 Iera Odos, 118 55 Athens, Greece;2. Plant Pathology Laboratory, Faculty of Agriculture, Aristotelian University of Thessaloniki, PO Box 269, 54124 Thessaloniki, Greece;1. Impulse Training Systems, Newnan, GA 30263, United States of America;2. University of Louisville, Louisville, KY 40292, United States of America |
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| Abstract: | Chromosomal aberrations, sister-chromatid exchanges and mitotic indices were observed in human peripheral leukocytes, treated with four different concentrations of malathion (0.02, 0.2, 2 and 20 μg/ml), an organophosphate pesticide, added to the culture medium at 0, 24 and 48 h after culture initiation. These cultures showed a dose-dependent increase in the frequency of chromosomal aberration as well as sister-chromatid exchanges. There was a significant decreases in mitotic index at all concentrations. |
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