Cold water swim stress inhibits the nociceptive responses to intrathecally administered somatostatin,but not substance P |
| |
| Institution: | 2. Doctor of Health Sciences Programme, International Doctoral School, Rey Juan Carlos University, Madrid, Spain;3. Department of Nursing and Stomatology, Faculty of Health Sciences, Rey Juan Carlos University, Madrid, Spain;4. Nursing Research Group, Gregorio Marañón Health Research Institute (IiSGM), Madrid, Spain;6. Department of Basic Health Sciences, Faculty of Health Sciences, Rey Juan Carlos University (URJC), Madrid, Spain;5. High Performance Research Group on Pathophysiology and Pharmacology of the Digestive Tract (NeuGut-URJC), Rey Juan Carlos University (URJC), Madrid, Spain;11. Spanish Pain Society Working Group on Cannabinoids, Madrid, Spain;12. Department of Nutrition, Faculty of Biomedicine and Nursing, Universidad Europea de Madrid, Madrid, Spain;8. Invecuid Care Research Group, Hospital 12 de Octubre Health Research Institute (imas12), Madrid, Spain |
| |
| Abstract: | The effects of cold water swim stress (CWSS) on the nociceptive responses to i.t. administered substance P (SP) and somatostatin (SST) were examined. Male ICR mice, weighing about 30 g, were forced to swim in water at 20°C for 3 min. In unstressed mice, i.t. injection of SP (0.1 nmol) and SST (1 nmol), respectively, produced nociceptive-related behaviors. Although CWSS had no effect on the intensity of the SP-induced nociceptive responses, CWSS significantly reduced the intensity of the SST-induced nociceptive responses. The effect of CWSS on the SST-induced nociceptive responses was blocked by naloxone (5 mg/kg, s.c.) and naltrindole (1 mg/kg, s.c.), a selective δ-opioid receptor antagonist, but not by β-funaltrexamine (20 mg/kg, s.c.), a selective μ-opioid receptor antagonist. These results indicate that CWSS may selectively reduce the SST-induced nociceptive responses primarily through δ-opioid receptors. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
