Topography of middle-latency somatosensory evoked potentials following painful laser stimuli and non-painful electrical stimuli |
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| Affiliation: | 1. Center for Hearing Research, Boys Town National Research Hospital, Omaha, NE, USA;2. Department of Hearing & Speech, University of Kansas Medical Center, Kansas City, KS, USA;1. Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, 200031, China;2. Department of Otolaryngology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, 200031, China;3. Department of Ophthalmology, Eye & ENT Hospital of Shanghai Medical School, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, 200031, China;4. Department of Radiology, Huashan Hospital of Shanghai Medical School, Fudan University, Shanghai, 200040, China;5. Department of Radiotherapy, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, 200031, China;6. Central Laboratory, Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, 200031, China;7. Health Statistics, Shanghai Medical School, Fudan University, Shanghai, 200031, China;8. Siemens Ltd. Healthcare sector, Shanghai, 201318, China;1. Neuropsychophysiology Laboratory, CIPsi School of Psychology, University of Minho, Braga, Portugal;2. CIPsi School of Psychology, University of Minho, Braga, Portugal;3. Department of Counseling and Applied Educational Psychology, Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA;4. Spaulding Center of Neuromodulation, Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;1. Department of Psychiatry and Behavioral Neuroscience, Anxiety Disorders Research Program, College of Medicine, University of Cincinnati, Box 670559, 260 Stetson Street, Suite 3200, Cincinnati, OH 45267-0559, USA;2. Division of Child and Adolescent Psychiatry, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA;3. Division of Clinical Pharmacology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA |
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| Abstract: | The aim of this study was to compare cerebral evoked potentials following selective activation of Aβ and Aδ fibers. In 15 healthy subjects, Aβ fibers were activated by electrical stimulation of the left radial nerve at the wrist. Aδ fibers were activated by short painful radian heat pulses, applied to the dorsum of the left hand by a CO2 laser. Evoked potentials were recorded with 15–27 scalp electrodes, evenly distributed over both hemispheres (bandpass 0.5–200 Hz). The laser-evoked potentials exhibited a component with a mean peak latency of 176 msec (N170). Its scalp topography showed a parieto-temporal maximum contralateral to the stimulus side. In contrast, the subsequent vertex negativity (N240), which appeared about 60 msec later, had a symmetrical scalp distribution. Electrically evoked potentials showed a component at 110 msec (N110), that had a topography similar to the laser-evoked N170. The topographies of the N170 and N110 suggest that they may both be generated in the secondary somatosensory cortex. There was no component in the electrically evoked potential that had a comparable interpeak latency to the following vertex potential: for N60 it was longer, for N110 it was shorter. On the other hand, in the laser-evoked potentials no component could be identified the topography of which corresponded to the primary cortical component N20 following electrical stimulation. |
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