Odor recognition and second messenger signaling in olfactory receptor neurons |
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| Institution: | 1. College of Plant Protection, Anhui Agricultural University, Hefei 230036, China;2. State Key Laboratory of Rice Biology, Key Laboratory of Agricultural Entomology, Ministry of Agriculture, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China;1. Biology Department, Università di Firenze, Italy;2. Department of Public Health & Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, University of Rome “Sapienza”, Rome, Italy;3. CISM, Mass Spectrometry Centre, Università di Firenze, Italy;4. Departments of Biological Sciences and Pharmacology, Vanderbilt University, Nashville, USA |
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| Abstract: | The detection of volatile odorants is supposed to begin with their interaction with soluble binding proteins which shuttle the hydrophobic ligands through the aqueous mucus layer towards specific odorant receptors in the ciliary membrane of olfactory neurons. A large family of receptors for odorants has been identified recently; individual receptor types are expressed in subsets of cells distributed in distinct zones of the olfactory epithelium. Ligand-receptor interaction triggers a rapid multistep reaction cascade, ultimately leading to an electrical response of the receptor neuron. Olfactory signaling is terminated by phosphorylation of receptors via a negative feedback reaction catalyzed by two types of kinases. |
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