The coiled body |
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| Authors: | Lamond A I Carmo-Fonseca M |
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| Institution: | European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 102209, D6900 Heidelberg, Germany. |
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| Abstract: | The coiled body is a nuclear organelle that contains snRNPs involved in splicing, the non-snRNP splicing factor U2AF and the nucleolar protein fibrillarin. It is highly conserved in evolution and is present in both animal and plant cells. The coiled body is a dynamic structure that can undergo regulated cycles of assembly and disassembly during interphase and mitosis and it may represent a distinct metabolic compartment within the nucleus. |
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