Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein |
| |
| Authors: | Beasley David W C Barrett Alan D T |
| |
| Institution: | WHO Collaborating Center for Tropical Diseases, Sealy Center for Vaccine Development, Department of Pathology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, USA. |
| |
| Abstract: | Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
