单核细胞的血管壁募集

在机体的许多病理生理过程中,均可见外周血单核细胞粘附于内皮表面,并向内皮下游走,这一现象称为单核细胞的血管壁募集。粘附分子和粘受体在这一过程中起重要作用,多种细胞因子和趋化因子参与了单核细胞募集的调节。本文将对单核细胞募集的过程及特点、单核细胞募集的机制、调节及生物学效应和意义进行概述。

Monocyte Recruitment in Blood Vessel Wall

Adhesion of monocytes to vascular endothelial cell(EC)and subsequent stretching and migration over the luminal surface of EC can be seen in some pathophysiological process in the body;This is called "monocyte recruitment". Adhesive molecules and adhesive receptors take part and play an important role in the process. The recruitment can be regulated by many cytokines and chemoattractants.In this article the process, character,mechanism,regulation and effect of monocyte recruitment will be discussed.