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A possible novel interaction between the 3′-end of 18 S ribosomal RNA and the 5'-leader sequence of many eukaryotic messenger RNAs
Authors:David R Sargan  Stephen P Gregory  Peter HW Butterworth
Institution:Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, England
Abstract:A novel interaction between the 5′-untranslated region of eukaryotic messenger RNAs and non-contiguous sequences in the 18 S ribosomal RNA is proposed. The small ribosomal RNA contains, at its 3′-terminus, a heavily conserved hairpin structure. It is suggested that mRNA 5′-leader sequence stabilises this structure by interacting with other conserved nucleotides which flank it. Sequences closely related to the required sequence (A—U—C—C—A—C—C) occur quite commonly in eukaryotic mRNAs and are often found immediately upstream from the AUG-codon. This interaction may have a role in the events which lead up to the initiation of protein synthesis.
Keywords:Eukaryotic mRNA  Secondary structure  of 18 S rRNA  Ribosome binding sites  Protein synthesis  initiation
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