A possible novel interaction between the 3′-end of 18 S ribosomal RNA and the 5'-leader sequence of many eukaryotic messenger RNAs |
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Authors: | David R Sargan Stephen P Gregory Peter HW Butterworth |
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Institution: | Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, England |
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Abstract: | A novel interaction between the 5′-untranslated region of eukaryotic messenger RNAs and non-contiguous sequences in the 18 S ribosomal RNA is proposed. The small ribosomal RNA contains, at its 3′-terminus, a heavily conserved hairpin structure. It is suggested that mRNA 5′-leader sequence stabilises this structure by interacting with other conserved nucleotides which flank it. Sequences closely related to the required sequence (A—U—C—C—A—C—C) occur quite commonly in eukaryotic mRNAs and are often found immediately upstream from the AUG-codon. This interaction may have a role in the events which lead up to the initiation of protein synthesis. |
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Keywords: | Eukaryotic mRNA Secondary structure of 18 S rRNA Ribosome binding sites Protein synthesis initiation |
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