Effects of heparin infusion on plasma lipoproteins in subjects with lipoprotein lipase deficiency: Evidence for a role of hepatic endothelial lipase in the metabolism of high-density lipoprotein subfractions in man |
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Authors: | SN Rao C Cortese NE Miller Y Levy B Lewis |
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Institution: | Department of Chemical Pathology and Metabolic Disorders, St. Thomas'' Hospital Medical School, London SE1 7EH, England |
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Abstract: | The role of heparin-releasable hepatic endothelial lipase (HL) in human plasma lipoprotein metabolism was investigated by examining the effects of intravenous infusion of heparin (180 units/kg over 2 h) in 8 subjects with primary extrahepatic lipoprotein lipase deficiency. In addition to reducing the triglyceride concentration in very low-density lipoproteins, heparin-induced release of HL reduced the phopholipid and protein concentrations in the HDL2 subclass of high-density lipoprotein (by 28% and 36% respectively, mean values) and simultaneously increased the HDL3 phospholipid concentration (by 23%), providing the first in vivo evidence for a function of HL in the interconversion of the major HDL subfractions in man. |
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Keywords: | Lipoproteins Hepatic lipase Heparin Hyperlipidaemia Lipoprotein lipase High-density lipoprotein |
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