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| 应力对大段骨缺损修复影响的实验兔模型探讨 | |
| 引用本文： | 吴琳,王禄增,哈斯达来,袁月,张劲松. 应力对大段骨缺损修复影响的实验兔模型探讨[J]. 中国实验动物学报, 2011, 19(1): 26-28,F0003. DOI: 10.3969/j.issn.1005-4847.2011.01.006 |
| 作者姓名： | 吴琳 王禄增 哈斯达来 袁月 张劲松 |
| 作者单位： | 1. 中国医科大学口腔医学院修复科,沈阳,110002 2. 中国医科大学实验动物部,沈阳,110001 3. 中国科学院金属研究所,沈阳,110016 |
| 基金项目： | 国家863计划资助项目，中科院金属研究所合作项目 |
| 摘 要： | 目的 建立用于研究应力对大段骨缺损修复作用的实验兔动物模型.方法 选用20只健康成年大耳白兔,随机分成两组,在右侧肱骨中下段制造13 mm的大段骨缺损后植入泡沫碳化硅人工骨,实验组选用具有固定和持续轴向加压双重作用的镍钛记忆合金接骨器,对照组选用同种材料和规格的仅有固定作用的接骨器,术后常规护理,待取材观察.结果 20只实验兔中,7只在苏醒后当天,10只术后1～3 d,3只术后4～7 d,出现植入体从植入部位脱出游离至皮下现象.结论 用于研究应力对大段骨缺损修复作用的实验兔动物模型未成功建立,镍钛记忆合金接骨器对兔肱骨大段骨缺损处人工骨的固定和持续加载,在实验兔肱骨难以实现. |
| 关 键 词： | 大段骨缺损 持续应力 泡沫碳化硅 镍钛记忆合金接骨器 动物模型 兔 |
Effect of stress on reconstruction of a large bone defect: establishment of an experimental rabbit model |
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| WU Lin,WANG Lu-zeng,HASI Da-lai,YUAN Yue,ZHANG Jing-song. Effect of stress on reconstruction of a large bone defect: establishment of an experimental rabbit model[J]. Acta Laboratorium Animalis Scientia Sinica, 2011, 19(1): 26-28,F0003. DOI: 10.3969/j.issn.1005-4847.2011.01.006 | |
| Authors: | WU Lin WANG Lu-zeng HASI Da-lai YUAN Yue ZHANG Jing-song |
| Affiliation: | WU Lin1,WANG Lu-zeng 2,HASI Da-lai1,YUAN Yue1,ZHANG Jing-song3(1.Department of Prosthodontics,School of Stomatology,China Medical University,Shenyang 110002,China,2.Laboratory Animal Center,Shenyang 110001,3.Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016) |
| Abstract: | Objective To establish an experimental rabbit model for studying the effect of the continuous compres-sive stress on reconstruction of a large bone defect.Methods Twenty adult Japanese rabbits were used and randomly di-vided into two groups.Artificial bone made of foam silicon carbide was implanted in a large bone defect in length of 13 mm at mid-distal humeral shaft of right side.Ni-Ti shape memory connector with both fixation and continuous compressive stress was used as the experimental group,and that wi... |
| Keywords: | Large bone defect Continuous stress Foam silicon carbide Ni-Ti shape-memory alloy connector Animal model rabbit |
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