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A virtual look at Epstein-Barr virus infection: simulation mechanism |
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| Authors: | Shapiro M Duca K A Lee K Delgado-Eckert E Hawkins J Jarrah A S Laubenbacher R Polys N F Hadinoto V Thorley-Lawson D A |
| Affiliation: | a Department of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA b Virginia Bioinformatics Institute, Virginia Polytechnic and State University, Washington Street, MC 0477, Blacksburg, VA 24061, USA c Research and Cluster Computing, Virginia Tech Information Technology, Virginia Polytechnic and State University, Blacksburg, VA 24061, USA |
| Abstract: | Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death. |
| Keywords: | Human herpesvirus 6 Agent based Biological model Computer model Viral persistence |
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