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A comparative analysis of kinetic models of erythrocyte glycolysis |
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| Authors: | du Preez F B Conradie R Penkler G P Holm K van Dooren F L J Snoep J L |
| Institution: | a Triple J Group for Molecular Cell Physiology, Department of Biochemistry, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa b Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK |
| Abstract: | Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. |
| Keywords: | 1 3-BPG 1 3-bisphosphoglycerate 2 3-BPG 2 3-bisphosphoglycerate 2-PGA 2-phosphoglycerate 3-PGA 3-phosphoglycerate 6-PGA 6-phosphogluconate 6-PGL 6-phosphogluconolactone ADE adenine ADO adenosine DHAP dihydroxyacetone phosphate Ery4P erythrose 4-phosphate F1 6BP fructose 1 6-bisphosphate F6P fructose 6-phosphate Glc glucose G6P glucose 6-phosphate GAP glyceraldehyde 3-phosphate HX hypoxanthine IMP inosine mono-phosphate INO inosine Lac lactate PEP phosphoenolpyruvate Pi inorganic phosphate PRPP 5-phosphoribosyl-1-pyrophosphate Pyr pyruvate Rib1P ribose 1-phosphate Rib5P ribose 5-phosphate Ru5P ribulose 5-phosphate Sed7P sedoheptulose 7-phosphate Xu5P xylulose 5-phosphate |
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