Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis |
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| Authors: | Vogiatzi Paraskevi Vindigni Carla Roviello Franco Renieri Alessandra Giordano Antonio |
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| Affiliation: | Department of Molecular Biology, Medical Genetics, University of Siena, Siena, Italy. |
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| Abstract: | Gastric cancer is a common aggressive malignancy. Although its incidence shows considerable variation among different countries, gastric cancer is still a major health problem worldwide. The causes of stomach cancer are not completely understood. What is clear is that gastric cancer is a multi-stage process involving genetic and epigenetic factors. This review is an in-depth study of the known genetic and epigenetic processes in the development of this tumor, and delineates possible approaches in gene and epigenetic therapy. |
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