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Decreased Insulin-Like Growth Factor-I and Its Receptor Expression in the Hippocampus and Somatosensory Cortex of the Aged Mouse |
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| Authors: | Choong Hyun Lee Ji Hyeon Ahn Joon Ha Park Bing Chun Yan In Hye Kim Dae Hwan Lee Jeong-Hwi Cho Bai Hui Chen Jae-Chul Lee Jun Hwi Cho Yun Lyul Lee Moo-Ho Won Il-Jun Kang |
| Institution: | 1. Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, 330-714, South Korea 2. Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea 3. Institute of Integrative Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, 225001, China 4. Laboratory of Neuroscience, Department of Physical Therapy, College of Rehabilitation Science, Daegu University, Gyeongsan, 712-714, South Korea 5. Department of Physiology, College of Medicine, Institute of Neurodegeneration and Neuroregeneration, Hallym University, Chuncheon, 200-702, South Korea 6. Department of Emergency Medicine, Institute of Medical Sciences, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea 7. Department of Food Science and Nutrition, Center for Aging and Health Care, Hallym University, Chuncheon, 200-702, South Korea |
| Abstract: | Insulin-like growth factor-I (IGF-I) is a multifunctional polypeptide and has diverse effects on brain functions. In the present study, we compared IGF-I and IGF-I receptor (IGF-IR) immunoreactivity and their protein levels between the adult (postnatal month 6) and aged (postnatal month 24) mouse hippocampus and somatosensory cortex. In the adult hippocampus, IGF-I immunoreactivity was easily observed in the pyramidal cells of the stratum pyramidale in the hippocampus proper and in the granule cells of the granule cell layer of the dentate gyrus. In the adult somatosensory cortex, IGF-I immunoreactivity was easily found in the pyramidal cells of layer V. In the aged groups, IGF-I expression was dramatically decreased in the cells. Like the change of IGF-I immunoreactivity, IGF-IR immunoreactivity in the pyramidal and granule cells of the hippocampus and in the pyramidal cells of the somatosensory cortex was also markedly decreased in the aged group. In addition, both IGF-I and IGF-IR protein levels were significantly decreased in the aged hippocampus and somatosensory cortex. These results indicate that the apparent decrease of IGF-I and IGF-IR expression in the aged mouse hippocampus and somatosensory cortex may be related to age-related changes in the aged brain. |
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