Lipid droplets as ubiquitous fat storage organelles in C. elegans |
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Authors: | Shaobing O Zhang Rhonda Trimble Fengli Guo Ho Yi Mak |
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Affiliation: | (1) Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA;(2) Deartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA |
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Abstract: | Background Lipid droplets are a class of eukaryotic cell organelles for storage of neutral fat such as triacylglycerol (TAG) and cholesterol ester (CE). We and others have recently reported that lysosome-related organelles (LROs) are not fat storage structures in the nematode C. elegans. We also reported the formation of enlarged lipid droplets in a class of peroxisomal fatty acid β-oxidation mutants. In the present study, we seek to provide further evidence on the organelle nature and biophysical properties of fat storage structures in wild-type and mutant C. elegans. |
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