Activation of p38 MAPK induces cell cycle arrest via inhibition of Raf/ERK pathway during muscle differentiation |
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Authors: | Lee Jinhwa Hong Feng Kwon Sijoong Kim Sam Soo Kim Dong Ok Kang Heung Sun Lee Su Jae Ha Joohun Kim Sung Soo |
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Institution: | Department of Biotechnology, Dongseo University, Pusan, Republic of Korea. |
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Abstract: | Cell cycle arrest is essential for initiation of muscle differentiation in myoblasts. Given the previously described essential role for p38 MAPK in myogenesis, we undertook the present study to investigate the role of p38 MAPK in the cell cycle arrest that initiates muscle differentiation. p38 MAPK activity increased during, and was required for, muscle differentiation. Inhibition of p38 MAPK stimulated Raf and ERK activities, and induced cell proliferation in differentiation medium. The concomitant inhibition of p38 MAPK and ERK, however, failed to induce differentiation or proliferation. In conclusion, inhibition of the Raf/ERK pathway and the consequent cell cycle arrest is one of the major functions of p38 MAPK during muscle differentiation. |
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Keywords: | p38 MAPK Raf ERK Muscle differentiation |
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