Fluorescence determination of enantiomeric composition of pharmaceuticals via use of ionic liquid that serves as both solvent and chiral selector |
| |
Authors: | Tran Chieu D Oliveira Daniel |
| |
Institution: | Department of Chemistry, Marquette University, Milwaukee, WI 53201, USA. chieu.tran@marquette.edu |
| |
Abstract: | A new method has been developed for the sensitive and accurate determination of enantiomeric compositions of a variety of drugs, including propranolol, naproxen, and warfarin. The method is based on the use of the fluorescence technique to measure diastereomeric interactions between both enantiomeric forms of a drug with an optically active room temperature ionic liquid (RTIL) followed by partial least squares analysis of the data. The chiral RTIL used in this study, S-(3-chloro-2-hydroxypropyl) trimethylammonium] bis((trifluoromethyl)sulfonyl)amide] (S-CHTA](+) Tf(2)N](-)), is a novel chiral RTIL that has been synthesized successfully recently in our laboratory in optically pure form using a simple one-step reaction with commercially available reagents. The high solubility power and strong enantiomeric recognition ability make it possible to use this chiral RTIL to solubilize a drug and to induce diastereomeric interactions for the determination of enantiomeric purity, that is, to use it as both solvent and chiral selector. Enantiomeric compositions of a variety of pharmaceutical products with different shapes, sizes, and functional groups can be determined sensitively (microgram concentration) and accurately (enantiomeric excess as low as 0.30% and enantiomeric impurity as low as 0.08%) by use of this method. |
| |
Keywords: | Chiral analysis Room temperature ionic liquid Fluorescence Drug Partial least square Enantiomeric excess Enantiomeric purity |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|