Bombesin-induced stimulation of cardiac parasympathetic innervation |
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Authors: | Laurel A Fisher Marvin R Brown |
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Institution: | Peptide Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, U.S.A. |
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Abstract: | The central nervous system effects of bombesin on cardiovascular function were examined in conscious, freely-moving rats. Intracerebroventricular administration of bombesin elevated mean arterial pressure, reduced heart rate and inhibited cold-induced tachycardia. Adrenalectomy prevented bombesin-induced elevations of mean arterial pressure. In contrast, bombesin-induced bradycardia was neither adrenal-dependent nor a baroreceptor-mediated reflex response to increased arterial pressure. Systemic atropine methyl nitrate treatment attenuated bombesin-induced bradycardia, suggesting that bombesin acts within the central nervous system to stimulate cardiac vagal activity. |
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Keywords: | bombesin neuropeptides autonomic nervous system bradycardia cardiovascular regulation |
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