The cholecystokinin antagonist,proglumide, increases food intake in the rat |
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Authors: | G. Shillabeer J.S. Davison |
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Affiliation: | Department of Medical Physiology, University of Calgary, Calgary, Alberta T2N 4N1, Canada |
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Abstract: | Cholecystokinin, secreted in response to ingested food entering the duodenum, may play a role in limiting food intake. Inhibition of cholecystokinin should therefore induce an increase in food intake. Proglumide, a specific antagonist of cholecystokinin was used to block the satiety effect of a food preload in rats. A significant increase in food intake was obtained following proglumide injection, thus supporting the hypothesis that cholecystokinin, released by food in the duodenum, acts as a short-term satiety factor. |
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Keywords: | hunger satiety food intake proglumide cholecystokinin antagonists |
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